Riley Lab

Rusali, L. E.*; Lopez-Hernandez, A. M.*; Kremiller, K. M.; Kulkarni, G. C.; Gour, A.; Straub, C. J.; Argade, M. D.; Peters, C. J.; Sharm, A.; Toll, L.; Cippitelli, A.; Riley, A. P. Synthesis of α3β4 Nicotinic Acetylcholine Receptor Modulators Derived from Aristoquinoline that Reduce Reinstatement of Cocaine-Seeking Behavior. Link to Pre-Print.

*Authors contributed equally to this work.

Hennessy, M. R.*; Gutridge, A. M*; French, A. R.; Rhoda, E. S.; Meqbil, Y. J.; Gill, M.; Kashyap, Y.; Appourchaux, K.; Paul, B.; Wang, Z. J.; van Rijn, R. M.; Riley, A. P. Modified Akuamma Alkaloids with Increased Potency at the Mu-opioid Receptor. J. Med. Chem. 2023, 66, 3312–3326. Link to Article.

*Authors contributed equally to this work.

Straub, C. J.; Rusali, L. E.; Kremiller, K. M.; Riley, A. P. What We Have Gained from Ibogaine: α3β4 Nicotinic Acetylcholine Receptor Inhibitors as Treatments for Substance Use Disorders. J. Med. Chem. 2023, 66, 107-121. Link to Article.

Featured on the Front Cover of Journal of Medicinal Chemistry.

Argade, M. D.; Riley, A. P. Syntheses of Aristotelia Alkaloids: Reflections in the Chiral Pool. Synlett 2022,  33, 1209-1214. Link to Article.

Argade, M. D.; Straub, C. J.; Rusali, L. E.; Santarsiero, B. D.; Riley, A. P. Synthesis of Aristoquinoline Enantiomers and Their Evaluation at the α3β4 Nicotinic Acetylcholine Receptor. Org. Lett. 2021, 23, 7693-7697. Link to Article

Featured on the Front Cover of Organic Letters.

Featured in Synfacts.

Creed, S.;* Gutridge, A.;* Argade, M. D.; Hennessy, M.; Friesen, J. B.; Pauli, G. F.; van Rijn, R.; Riley, A. P. Isolation and Pharmacological Characterization of Six Opioidergic Picralima nitida Alkaloids. J. Nat. Prod. 2021, 84, 71-80. Link to Article

*Authors contributed equally to this work.

• Crowley, R. S.; Riley, A. P.; Alder, A. F.; Anderson, R. J.; Luo, D.; Kaska, S.; Maynez P.; Kivell, B. M.; Prisinzano, T. E. Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Design, Synthesis, and Evaluation of Analogues with Improved Potency and G-protein Activation Bias at the μ-Opioid Receptor, ACS Chem. Neurosci. 2020, 11, 1781-1790. Link to Article
• Richter, M. F.; Drown, B. S.; Riley, A.P.; Garcia, A.; Shirai, T.; Svec, R. L.; Hergenrother, P. J. Predictive Compound Accumulation Rules Yield a Broad-spectrum Antibiotic, Nature, 2017, 545, 299-304. Link to Article
• Crowley R. S.*; Riley A. P.*; Sherwood A. M.; Groer C.E.; Shivaperumal N.; Biscaia M.; Paton K.; Schneider S.; Provasi D.; Kivell B. M.; Filizola M.; Prisinzano T. E. Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ-Opioid Analgesic with Reduced Abuse Liability, J. Med. Chem. 2016, 59, 11027-11038.   *Authors contributed equally to this work Link to Article
• Meneely, K. M.; Ronnebaum, T. A.; Riley, A. P.; Prisinzano, T. E.; Lamb, A. L. Holo Structure and Steady State Kinetics of the Thiazolinyl Imine Reductases for Siderophore Biosynthesis, Biochemistry, 2016, 55, 5423-5433. Link to Article
• Paranjape S. R.; Riley, A. P.; Somoza, A. D.; Oakley, C. E.; Wang, C. C.; Prisinzano, T. E. Oakley, B. R.; Gamblin, T. C. Azaphilones Inhibit Tau Aggregation and Dissolve Tau Aggregates In Vitro, ACS Chem. Neurosci. 2015,6,751-760. Link to Article
• Riley, A. P.; Groer, C. E.; Young, D.; Ewald A. W. Kivell, B. M. Prisinzano, T. E. Synthesis and κ-Opioid Receptor Activity of Furan-substituted Salvinorin A Analogues. J.  Med. Chem. 2014, 57, 10464-10475. Link to Article
• Meneely, K. M.; Luo, Q.;Riley, A. P.; Taylor, B.; Roy, A.; Stein, R. L.; Prisinzano, T. E.; Lamb, A. L. Expanding the Results of a High Throughput Screen Against an Isochorismate-pyruvate Lyase to Enzymes of a Similar Scaffold or Mechanism. Biorg. Med. Chem. 2014, 22, 5961-5969. Link to Article
• Riley, A. P.; Day, V. W.; Navarro, H. A.; Prisinzano, T. E. Palladium-catalyzed Transformations of Salvinorin A, A Diterpene from Salvia divinorum.  Org. Lett. 2013, 15, 5936-5939. Link to Article